Asthma Management and Education Asthma and Allergy Foundation of America - Information About Asthma, Allergies, Food Allergies and More! This course hurt my brain. But it's FREE brain damage Example: In some allergic individuals, there is a second, "late-phase" response, which takes place over a longer timeframe. ... Some of the mediators released in the early phase - leukotrienes, for example - attract more inflammatory cells such as eosinophils and neutrophils to the site by a process known as "chemotaxis." These new inflammatory cells are then activated by cytokines - mediators released earlier by lymphocytes. On activation, these cells release a second wave of inflammatory mediators which are very toxic and cause the more severe and difficult to treat late-phase response approximately 6-10 hours after the original exposure.